A novel nitidine chloride nanoparticle overcomes the stemness of CD133<sup>+</sup>EPCAM<sup>+</sup> Huh7 hepatocellular carcinoma cells for liver cancer therapy.

Li, Danni; Zhang, Qiying; Zhou, Yuzhu; Zhu, Hua; Li, Tong; Du, Fangkai

A novel nitidine chloride nanoparticle overcomes the stemness of CD133⁺EPCAM⁺ Huh7 hepatocellular carcinoma cells for liver cancer therapy.

Li, Danni; Zhang, Qiying; Zhou, Yuzhu; Zhu, Hua; Li, Tong; Du, Fangkai.

Affiliation

Li D; School of Chemistry and Chemical Eengineering, Guangxi Minzu University, No.158, Da Xue Xi street, Xixiangtang District, Nanning, 530006, Guangxi Province, China. lidanni@gxmzu.edu.cn.
Zhang Q; School of Chemistry and Chemical Eengineering, Guangxi Minzu University, No.158, Da Xue Xi street, Xixiangtang District, Nanning, 530006, Guangxi Province, China.
Zhou Y; School of Chemistry and Chemical Eengineering, Guangxi Minzu University, No.158, Da Xue Xi street, Xixiangtang District, Nanning, 530006, Guangxi Province, China.
Zhu H; College of Pharmacy, Guangxi University for Chinese Medicine, No.13 , Wu He street, Qingxiu District, Nanning, 530200, Guangxi Province, China.
Li T; College of Pharmacy, Guangxi University for Chinese Medicine, No.13 , Wu He street, Qingxiu District, Nanning, 530200, Guangxi Province, China.
Du F; School of Chemistry and Chemical Eengineering, Guangxi Minzu University, No.158, Da Xue Xi street, Xixiangtang District, Nanning, 530006, Guangxi Province, China.

BMC Pharmacol Toxicol ; 23(1): 48, 2022 07 12.

Article in En | MEDLINE | ID: mdl-35820920

Subject(s)

Carcinoma, Hepatocellular; Liver Neoplasms; Nanoparticles; Neoplastic Stem Cells; AC133 Antigen/metabolism; Animals; Benzophenanthridines; Carcinoma, Hepatocellular/drug therapy; Carcinoma, Hepatocellular/metabolism; Carcinoma, Hepatocellular/pathology; Cell Line, Tumor; Epithelial Cell Adhesion Molecule; Humans; Liver Neoplasms/drug therapy; Liver Neoplasms/metabolism; Liver Neoplasms/pathology; Mice; Mice, Nude; Nanoparticles/administration & dosage; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology

Key words

AQP3/STAT3/CD133 pathway; EpCAM+ /CD133+ Huh7 cells; Huh7 cells xenograft nude mice; Nitidine chloride nanoparticles

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Carcinoma, Hepatocellular / Nanoparticles / Liver Neoplasms Limits: Animals / Humans Language: En Journal: BMC Pharmacol Toxicol Year: 2022 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google