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Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.
Sioofy-Khojine, Amir-Babak; Richardson, Sarah J; Locke, Jonathan M; Oikarinen, Sami; Nurminen, Noora; Laine, Antti-Pekka; Downes, Kate; Lempainen, Johanna; Todd, John A; Veijola, Riitta; Ilonen, Jorma; Knip, Mikael; Morgan, Noel G; Hyöty, Heikki; Peakman, Mark; Eichmann, Martin.
Affiliation
  • Sioofy-Khojine AB; Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Richardson SJ; Exeter Centre of Excellence for Diabetes Research (EXCEED), Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
  • Locke JM; Exeter Centre of Excellence for Diabetes Research (EXCEED), Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
  • Oikarinen S; Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Nurminen N; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.
  • Laine AP; Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Downes K; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.
  • Lempainen J; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
  • Todd JA; Cambridge University Hospitals Genomics Laboratory, Cambridge University Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.
  • Veijola R; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.
  • Ilonen J; Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
  • Knip M; Clinical Microbiology, Turku University Hospital, Turku, Finland.
  • Morgan NG; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
  • Hyöty H; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, National Institute for Health and Care Research/Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Peakman M; Department for Children and Adolescents, Oulu University Hospital, Oulu, Finland.
  • Eichmann M; Department of Paediatrics, Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Diabetologia ; 65(10): 1701-1709, 2022 10.
Article in En | MEDLINE | ID: mdl-35867130
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enterovirus / Diabetes Mellitus, Type 1 / Enterovirus Infections / Insulins Type of study: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limits: Adult / Child / Humans Language: En Journal: Diabetologia Year: 2022 Type: Article Affiliation country: Finland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enterovirus / Diabetes Mellitus, Type 1 / Enterovirus Infections / Insulins Type of study: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limits: Adult / Child / Humans Language: En Journal: Diabetologia Year: 2022 Type: Article Affiliation country: Finland