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Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
Shukla, Rhythm; Lavore, Francesca; Maity, Sourav; Derks, Maik G N; Jones, Chelsea R; Vermeulen, Bram J A; Melcrová, Adéla; Morris, Michael A; Becker, Lea Marie; Wang, Xiaoqi; Kumar, Raj; Medeiros-Silva, João; van Beekveld, Roy A M; Bonvin, Alexandre M J J; Lorent, Joseph H; Lelli, Moreno; Nowick, James S; MacGillavry, Harold D; Peoples, Aaron J; Spoering, Amy L; Ling, Losee L; Hughes, Dallas E; Roos, Wouter H; Breukink, Eefjan; Lewis, Kim; Weingarth, Markus.
Affiliation
  • Shukla R; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Lavore F; Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Maity S; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Derks MGN; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, The Netherlands.
  • Jones CR; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Vermeulen BJA; Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Melcrová A; Department of Chemistry, University of California Irvine, Irvine, CA, USA.
  • Morris MA; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Becker LM; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, The Netherlands.
  • Wang X; Department of Chemistry, University of California Irvine, Irvine, CA, USA.
  • Kumar R; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Medeiros-Silva J; Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • van Beekveld RAM; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Bonvin AMJJ; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Lorent JH; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Lelli M; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Nowick JS; Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • MacGillavry HD; Magnetic Resonance Center (CERM) and Department of Chemistry 'Ugo Schiff', University of Florence, Sesto Fiorentino (FI), Italy.
  • Peoples AJ; Consorzio Interuniversitario Risonanze Magnetiche MetalloProteine (CIRMMP), Sesto Fiorentino, Florence, Italy.
  • Spoering AL; Department of Chemistry, University of California Irvine, Irvine, CA, USA.
  • Ling LL; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Hughes DE; NovoBiotic Pharmaceuticals, Cambridge, MA, USA.
  • Roos WH; NovoBiotic Pharmaceuticals, Cambridge, MA, USA.
  • Breukink E; NovoBiotic Pharmaceuticals, Cambridge, MA, USA.
  • Lewis K; NovoBiotic Pharmaceuticals, Cambridge, MA, USA.
  • Weingarth M; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, The Netherlands.
Nature ; 608(7922): 390-396, 2022 08.
Article in En | MEDLINE | ID: mdl-35922513
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / Cell Membrane / Depsipeptides / Microbial Viability / Anti-Bacterial Agents Limits: Humans Language: En Journal: Nature Year: 2022 Type: Article Affiliation country: Netherlands
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / Cell Membrane / Depsipeptides / Microbial Viability / Anti-Bacterial Agents Limits: Humans Language: En Journal: Nature Year: 2022 Type: Article Affiliation country: Netherlands