4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson's Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation.

Tiwari, Shubhangini; Gupta, Parul; Singh, Abhishek; Chaturvedi, Swati; Wahajuddin, M; Mishra, Amit; Singh, Sarika

Tiwari, Shubhangini; Gupta, Parul; Singh, Abhishek; Chaturvedi, Swati; Wahajuddin, M; Mishra, Amit; Singh, Sarika.

Affiliation

Tiwari S; Division of Neuroscience and Ageing Biology, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Gupta P; Division of Neuroscience and Ageing Biology, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Singh A; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, India.
Chaturvedi S; Division of Neuroscience and Ageing Biology, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Wahajuddin M; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, India.
Mishra A; Division of Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Singh S; Division of Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.

Neurochem Res ; 47(11): 3385-3401, 2022 Nov.

Article in En | MEDLINE | ID: mdl-35922743

Subject(s)

Motor Disorders; Neuroprotective Agents; Parkinson Disease; Animals; Astrocytes/metabolism; Calcium/metabolism; Caspase 3/metabolism; Cytochromes/metabolism; Cytochromes/pharmacology; Cytochromes/therapeutic use; Disease Models, Animal; Dopamine/metabolism; Dopaminergic Neurons; Histone Deacetylases/metabolism; Mitochondria/metabolism; Motor Disorders/drug therapy; Motor Disorders/metabolism; Motor Disorders/pathology; Neuroprotective Agents/metabolism; Neuroprotective Agents/pharmacology; Neuroprotective Agents/therapeutic use; Nitrites/metabolism; Parkinson Disease/metabolism; Phenylbutyrates; Protein Aggregates; Rats; Tyrosine 3-Monooxygenase/metabolism; Voltage-Dependent Anion Channel 1/metabolism; Voltage-Dependent Anion Channel 1/therapeutic use; alpha-Synuclein/metabolism; bcl-2-Associated X Protein/metabolism

Key words

4-Phenyl butyric acid (4PBA); Mitochondrial dysfunction; Neuroprotection; Oxidative stress; Parkinson's disease; Preclinical findings; Repurposing of drug

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Neuroprotective Agents / Motor Disorders Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurochem Res Year: 2022 Type: Article Affiliation country: India

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