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Spike-heparan sulfate interactions in SARS-CoV-2 infection.
Kearns, Fiona L; Sandoval, Daniel R; Casalino, Lorenzo; Clausen, Thomas M; Rosenfeld, Mia A; Spliid, Charlotte B; Amaro, Rommie E; Esko, Jeffrey D.
Affiliation
  • Kearns FL; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/fiona_chembot.
  • Sandoval DR; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Casalino L; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/LCasalino88.
  • Clausen TM; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Rosenfeld MA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/mia_rosenfeld.
  • Spliid CB; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Amaro RE; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/RommieAmaro.
  • Esko JD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: jesko@health.ucsd.edu.
Curr Opin Struct Biol ; 76: 102439, 2022 10.
Article in En | MEDLINE | ID: mdl-35926454
ABSTRACT
Recent biochemical, biophysical, and genetic studies have shown that heparan sulfate, a major component of the cellular glycocalyx, participates in infection of SARS-CoV-2 by facilitating the so-called open conformation of the spike protein, which is required for binding to ACE2. This review highlights the involvement of heparan sulfate in the SARS-CoV-2 infection cycle and argues that there is a high degree of coordination between host cell heparan sulfate and asparagine-linked glycans on the spike in enabling ACE2 binding and subsequent infection. The discovery that spike protein binding and infection depends on both viral and host glycans provides insights into the evolution, spread and potential therapies for SARS-CoV-2 and its variants.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: Curr Opin Struct Biol Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: Curr Opin Struct Biol Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article