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Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors.
Saccoccia, Fulvio; Pozzetti, Luca; Gimmelli, Roberto; Butini, Stefania; Guidi, Alessandra; Papoff, Giuliana; Giannaccari, Marialaura; Brogi, Simone; Scognamiglio, Viviana; Gemma, Sandra; Ruberti, Giovina; Campiani, Giuseppe.
Affiliation
  • Saccoccia F; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy. Electronic address: fulvio.saccoccia@cnr.it.
  • Pozzetti L; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy.
  • Gimmelli R; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy.
  • Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy.
  • Guidi A; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy.
  • Papoff G; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy.
  • Giannaccari M; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy.
  • Brogi S; Department of Pharmacy, University of Pisa, Pisa, Italy.
  • Scognamiglio V; Institute of Crystallography, Italian National Research Council, Department of Chemical Sciences and Materials Technologies, Monterotondo, Italy.
  • Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy.
  • Ruberti G; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy. Electronic address: giovina.ruberti@cnr.it.
  • Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy. Electronic address: campiani@unisi.it.
J Biol Chem ; 298(10): 102375, 2022 10.
Article in En | MEDLINE | ID: mdl-35970392
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schistosoma mansoni / Helminth Proteins / Histone Deacetylase Inhibitors / Histone Deacetylases / Anthelmintics Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2022 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schistosoma mansoni / Helminth Proteins / Histone Deacetylase Inhibitors / Histone Deacetylases / Anthelmintics Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2022 Type: Article