Maillard Reaction Products with Anti-Tobacco Mosaic Virus Activities Generated in Processed Thermopsis lanceolata R. Br. Seed Extract.
J Org Chem
; 87(17): 11309-11318, 2022 09 02.
Article
in En
| MEDLINE
| ID: mdl-35981284
ABSTRACT
Six novel Maillard reaction products (MRPs) (1-6) were isolated from the processed Thermopsis lanceolata R. Br. seed extract, along with one biogenetically related intermediate (7). Compounds 1-4 possessed three rare dimerization patterns constructed by cytisine, whereas compounds 5 and 6 represented the first example of the addition products of cytisine and 5,6-dihydroxy-4-hexanolide. Their structures were elucidated by comprehensive spectroscopic data analysis and quantum chemistry calculations including GIAO 13C{1H} NMR and ECD calculation, combined with single-crystal X-ray diffraction analysis. Biologically, compound 3 displayed significant anti-tobacco mosaic virus activity compared with the positive control ningnanmycin.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tobacco Mosaic Virus
Language:
En
Journal:
J Org Chem
Year:
2022
Type:
Article