Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis.
Clin Oral Investig
; 26(12): 7209-7218, 2022 Dec.
Article
in En
| MEDLINE
| ID: mdl-35986791
ABSTRACT
OBJECTIVES:
IL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1ß and periostin. MATERIALS ANDMETHODS:
Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1ß, and periostin levels were examined using the enzyme-linked immunosorbent assay.RESULTS:
GCF IL1ß, periostin, and IL-39 levels were higher in the P and G groups than in the PH group (p < 0.001). Positive correlations were detected between all GCF biochemical parameters and clinical periodontal parameters (p < 0.05). In the multivariate generalized linear regression analysis, the P (ß = 37.6, 95% CI = 22.9-52.4) and G (ß = 28.4, 95% CI = 15.8-41) groups were associated with GCF IL-39 levels (p < 0.001).CONCLUSION:
IL-39 levels were elevated in the presence of periodontal disease paralleling the increase in IL1ß and periostin levels. IL-39 may have a role in the periodontal inflammation process. STATEMENT OF CLINICAL RELEVANCE IL-39, a new cytokine from the IL-12 family, can be a possible predictor marker of periodontal diseases.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chronic Periodontitis
/
Gingivitis
Type of study:
Prognostic_studies
Limits:
Adult
/
Humans
Language:
En
Journal:
Clin Oral Investig
Journal subject:
ODONTOLOGIA
Year:
2022
Type:
Article
Affiliation country:
Turkey