Saliva microbiome, dietary, and genetic markers are associated with suicidal ideation in university students.
Sci Rep
; 12(1): 14306, 2022 08 22.
Article
in En
| MEDLINE
| ID: mdl-35995968
ABSTRACT
Here, salivary microbiota and major histocompatibility complex (MHC) human leukocyte antigen (HLA) alleles were compared between 47 (12.6%) young adults with recent suicidal ideation (SI) and 325 (87.4%) controls without recent SI. Several bacterial taxa were correlated with SI after controlling for sleep issues, diet, and genetics. Four MHC class II alleles were protective for SI including DRB1*04, which was absent in every subject with SI while present in 21.7% of controls. Increased incidence of SI was observed with four other MHC class II alleles and two MHC class I alleles. Associations between these HLA alleles and salivary bacteria were also identified. Furthermore, rs10437629, previously associated with attempted suicide, was correlated here with SI and the absence of Alloprevotella rava, a producer of an organic acid known to promote brain energy homeostasis. Hence, microbial-genetic associations may be important players in the diathesis-stress model for suicidal behaviors.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Suicidal Ideation
/
Microbiota
Type of study:
Risk_factors_studies
Limits:
Adult
/
Humans
Language:
En
Journal:
Sci Rep
Year:
2022
Type:
Article
Affiliation country:
United States