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EZH2 restricts Tcf7 DNA methylation and promotes TFH differentiation during acute viral infection.
Luo, Yuan; Li, Dan; Xie, Luoyingzi; Lei, Shun; Chen, Xiangyu; Wang, Cong; Yao, Dong; Li, Lin; Fang, Jingyi; Chen, Cheng; Yuan, Shijie; Li, Fei; Xie, Xiaorong; Zhang, Yan; Li, Zhirong; Hu, Li; Tang, Jianfang; Ye, Lilin; Wei, Zhengping; He, Ran.
Affiliation
  • Luo Y; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li D; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Xie L; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Lei S; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Chen X; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Wang C; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Yao D; Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China.
  • Li L; Department of Anesthesiology, Chongqing Public Health Medical Center, Chongqing, China.
  • Fang J; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chen C; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Yuan S; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Li F; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xie X; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang Y; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li Z; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Hu L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Tang J; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Ye L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Wei Z; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • He R; Institute of Immunology, Third Military Medical University, Chongqing, China.
Front Immunol ; 13: 942465, 2022.
Article in En | MEDLINE | ID: mdl-36045674
ABSTRACT
Follicular helper T (TFH) cells provide specialized help for B cells to ensure optimal humoral immunity. The histone methyltransferase EZH2, as a chromatin repressor, secures the TFH differentiation by promoting TFH lineage associated gene expression during acute viral infection, including Tcf7 and Bcl6. By using conditional deletion murine system, we observed that EZH2 ablation in CD4+ T cells was accompanied by aberrant accumulation of DNA methyltransferases (DNMTs) DNMT1 and DNMT3B in TFH cells. And the loss of EZH2 promoted aggravation of DNA methylation status at Tcf7 locus. Therefore, our findings suggested that EZH2 plays an important role in maintenance of hypomethylation at Tcf7 locus thus affecting TFH differentiation during acute viral infection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virus Diseases / T-Lymphocytes, Helper-Inducer / DNA Methylation / Hepatocyte Nuclear Factor 1-alpha / Enhancer of Zeste Homolog 2 Protein Limits: Animals Language: En Journal: Front Immunol Year: 2022 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virus Diseases / T-Lymphocytes, Helper-Inducer / DNA Methylation / Hepatocyte Nuclear Factor 1-alpha / Enhancer of Zeste Homolog 2 Protein Limits: Animals Language: En Journal: Front Immunol Year: 2022 Type: Article Affiliation country: China