Influence of minor plant constituents on porcine hepatic lipid metabolism. Impact on serum lipids.
Atherosclerosis
; 64(2-3): 109-15, 1987 Apr.
Article
in En
| MEDLINE
| ID: mdl-3606707
ABSTRACT
The effects of plant constituents on lipid metabolism were examined in swine that had been fed for 4 weeks a standard diet containing, in addition, (per kg diet) 3.15 g of the methanol serial solvent fraction garlic bulbs or 3.5 g of the petroleum ether solubles high-protein barley flour or 5 mg of the plant growth regulator, AMO 1618. All treatments suppressed 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and cholesterol 7 alpha-hydroxylase activities. Modest increases in serum triglycerides were associated with significantly increased hepatic lipogenic activities in response to all treatments except that of the barley extract. The methanol solubles of a second lot of garlic were fractionated by HPLC and tested in an avian hepatocyte system. One component, an isoprenoid metabolite, MW 358, suppressed HMG-CoA reductase.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plants, Medicinal
/
Swine
/
Hordeum
/
Edible Grain
/
Lipid Metabolism
/
Garlic
/
Liver
/
Animal Feed
Limits:
Animals
Language:
En
Journal:
Atherosclerosis
Year:
1987
Type:
Article