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Safety Evaluation of Employing Temporal Interference Transcranial Alternating Current Stimulation in Human Studies.
Piao, Yi; Ma, Ru; Weng, Yaohao; Fan, Chuan; Xia, Xinzhao; Zhang, Wei; Zeng, Ginger Qinghong; Wang, Yan; Lu, Zhuo; Cui, Jiangtian; Wang, Xiaoxiao; Gao, Li; Qiu, Bensheng; Zhang, Xiaochu.
Affiliation
  • Piao Y; Application Technology Center of Physical Therapy to Brain Disorders, Institute of Advanced Technology, University of Science & Technology of China, Hefei 230031, China.
  • Ma R; Department of Radiology, The First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science & Technology of China, Hefei 230027, China.
  • Weng Y; Department of Radiology, The First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science & Technology of China, Hefei 230027, China.
  • Fan C; Centers for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.
  • Xia X; Department of Psychiatry, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
  • Zhang W; Centers for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.
  • Zeng GQ; Department of Radiology, The First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science & Technology of China, Hefei 230027, China.
  • Wang Y; Application Technology Center of Physical Therapy to Brain Disorders, Institute of Advanced Technology, University of Science & Technology of China, Hefei 230031, China.
  • Lu Z; Department of Radiology, The First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science & Technology of China, Hefei 230027, China.
  • Cui J; Centers for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.
  • Wang X; Centers for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.
  • Gao L; School of Optometry and Vision Science, Cardiff University, Cardiff CF24 4HQ, UK.
  • Qiu B; Centers for Biomedical Engineering, School of Information Science and Technology, University of Science and Technology of China, Hefei 230027, China.
  • Zhang X; SILC Business School, Shanghai University, Shanghai 201800, China.
Brain Sci ; 12(9)2022 Sep 05.
Article in En | MEDLINE | ID: mdl-36138930
ABSTRACT
Temporal interference transcranial alternating current stimulation (TI-tACS) is a new technique of noninvasive brain stimulation. Previous studies have shown the effectiveness of TI-tACS in stimulating brain areas in a selective manner. However, its safety in modulating human brain neurons is still untested. In this study, 38 healthy adults were recruited to undergo a series of neurological and neuropsychological measurements regarding safety concerns before and after active (2 mA, 20/70 Hz, 30 min) or sham (0 mA, 0 Hz, 30 min) TI-tACS. The neurological and neuropsychological measurements included electroencephalography (EEG), serum neuron-specific enolase (NSE), the Montreal Cognitive Assessment (MoCA), the Purdue Pegboard Test (PPT), an abbreviated version of the California Computerized Assessment Package (A-CalCAP), a revised version of the Visual Analog Mood Scale (VAMS-R), a self-assessment scale (SAS), and a questionnaire about adverse effects (AEs). We found no significant difference between the measurements of the active and sham TI-tACS groups. Meanwhile, no serious or intolerable adverse effects were reported or observed in the active stimulation group of 19 participants. These results support that TI-tACS is safe and tolerable in terms of neurological and neuropsychological functions and adverse effects for use in human brain stimulation studies under typical transcranial electric stimulation (TES) conditions (2 mA, 20/70 Hz, 30 min).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Brain Sci Year: 2022 Type: Article Affiliation country: China
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Brain Sci Year: 2022 Type: Article Affiliation country: China