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Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.
Pilo, Caila A; Baffi, Timothy R; Kornev, Alexandr P; Kunkel, Maya T; Malfavon, Mario; Chen, Dong-Hui; Rossitto, Leigh-Ana; Chen, Daniel X; Huang, Liang-Chin; Longman, Cheryl; Kannan, Natarajan; Raskind, Wendy H; Gonzalez, David J; Taylor, Susan S; Gorrie, George; Newton, Alexandra C.
Affiliation
  • Pilo CA; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
  • Baffi TR; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA.
  • Kornev AP; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
  • Kunkel MT; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
  • Malfavon M; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
  • Chen DH; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
  • Rossitto LA; Department of Neurology, University of Washington, Seattle, WA 98195, USA.
  • Chen DX; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
  • Huang LC; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA.
  • Longman C; Department of Neurology, University of Washington, Seattle, WA 98195, USA.
  • Kannan N; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
  • Raskind WH; Queen Elizabeth University Hospital, Glasgow, Scotland G51 4TF, UK.
  • Gonzalez DJ; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
  • Taylor SS; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
  • Gorrie G; Department of Medicine/Medical Genetics, University of Washington, Seattle, WA 98195, USA.
  • Newton AC; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.
Sci Signal ; 15(753): eabk1147, 2022 Sep 27.
Article in En | MEDLINE | ID: mdl-36166510
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinocerebellar Ataxias / Diglycerides Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2022 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinocerebellar Ataxias / Diglycerides Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2022 Type: Article Affiliation country: United States