p300/CBP sustains Polycomb silencing by non-enzymatic functions.

Hunt, George; Boija, Ann; Mannervik, Mattias

Hunt, George; Boija, Ann; Mannervik, Mattias.

Affiliation

Hunt G; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden.
Boija A; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Mannervik M; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden. Electronic address: mattias.mannervik@su.se.

Mol Cell ; 82(19): 3580-3597.e9, 2022 10 06.

Article in En | MEDLINE | ID: mdl-36206738

Subject(s)

Drosophila Proteins; Nucleosomes; Animals; CREB-Binding Protein/genetics; CREB-Binding Protein/metabolism; Chromatin/genetics; Chromatin/metabolism; DNA/metabolism; Drosophila/genetics; Drosophila/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Mice; Nucleosomes/genetics; Nucleosomes/metabolism; Polycomb Repressive Complex 1/genetics; Polycomb-Group Proteins/metabolism; Protein Binding; RNA/metabolism; RNA Polymerase II/genetics; RNA Polymerase II/metabolism

Key words

CBP; Pol II pausing; Polycomb; R-loop; epigenetics; gene silencing; nucleosome depletion; p300; transcription

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nucleosomes / Drosophila Proteins Limits: Animals Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: Sweden

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