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Quantitative Model Analysis and Simulation of Pharmacokinetics and Metastasis-Associated Lung Adenocarcinoma 1 RNA Knockdown Effect After Systemic Administration of Cholesterol-Conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice.
Goto, Akihiko; Yamamoto, Syunsuke; Igari, Tomoko; Matsumoto, Shin-Ichi; Chisaki, Ikumi; Iida, Koichi; Nakayama, Miyu; Oda, Akira; Kakoi, Yuuichi; Uchida, Akio; Miyata, Kenichi; Nishikawa, Makiya; Nagata, Tetsuya; Kusuhara, Hiroyuki; Yokota, Takanori; Hirabayashi, Hideki.
Affiliation
  • Goto A; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Yamamoto S; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Igari T; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Matsumoto SI; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Chisaki I; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Iida K; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Nakayama M; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Oda A; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Kakoi Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Uchida A; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Miyata K; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Nishikawa M; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Nagata T; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Kusuhara H; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Yokota T; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
  • Hirabayashi H; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.G., S.Y., T.I., S.M., I.C., K.I., Mi.N., H.H.); Neuroscience Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan (A.O., Y.K.); Asia New Chemical Entity Produc
J Pharmacol Exp Ther ; 384(1): 197-204, 2023 01.
Article in En | MEDLINE | ID: mdl-36273821
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / RNA Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2023 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / RNA Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2023 Type: Article