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Diterpenoid alkaloids from two species of Delphinium.
Huang, Shuai; Wang, Jian-Zhu; Guo, Qiu-Ju; Xiao, Yan; Feng, Yu-Ming; Chen, Lin; Xie, Jiang; Zhou, Xian-Li.
Affiliation
  • Huang S; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
  • Wang JZ; Yibin Institute of Southwest Jiaotong University, Yibin 644000, China.
  • Guo QJ; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
  • Xiao Y; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
  • Feng YM; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
  • Chen L; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
  • Xie J; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
  • Zhou XL; The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610000, China.
J Asian Nat Prod Res ; 25(8): 718-730, 2023.
Article in En | MEDLINE | ID: mdl-36331432
Four new compounds (1-4) were isolated from the whole plants of two species of Delphinium, including two C20-diterpenoid alkaloids, umbrodines A and B (1 and 2), and a dibenzoxazepinone, umbrolide A (3) from Delphinium umbrosum Hand.-Mazz. and a C20-diterpenoid alkaloid, kingiadine (4) from Delphinium kingianum Bruhl. ex Huth. Ten known diterpenoid alkaloids were also isolated. Their structures were elucidated via HR-ESIMS, IR, and NMR data. Lycoctonine (11) and delectinine (12) exhibited appreciable cardiac activity. Furthermore, 11 and 12 showed cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells, with the maximum protection rates of 61.63% and 51.18%, respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2023 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2023 Type: Article Affiliation country: China