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GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome.
Tiberti, Silvia; Catozzi, Carlotta; Croci, Ottavio; Ballerini, Mattia; Cagnina, Danilo; Soriani, Chiara; Scirgolea, Caterina; Gong, Zheng; He, Jiatai; Macandog, Angeli D; Nabinejad, Amir; Nava Lauson, Carina B; Quinte', Arianna; Bertalot, Giovanni; Petz, Wanda L; Ravenda, Simona P; Licursi, Valerio; Paci, Paola; Rasponi, Marco; Rotta, Luca; Fazio, Nicola; Ren, Guangwen; Fumagalli-Romario, Uberto; Schaefer, Martin H; Campaner, Stefano; Lugli, Enrico; Nezi, Luigi; Manzo, Teresa.
Affiliation
  • Tiberti S; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Catozzi C; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Croci O; Center for Genomic Science of IIT, CGS@SEMM (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), Milano, Italy.
  • Ballerini M; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Cagnina D; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Soriani C; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Scirgolea C; Laboratory of Translational Immunology, IRCCS- Humanitas Research Hospital-, Milan, Italy.
  • Gong Z; The Jackson Laboratory, Bar Harbor, ME, USA.
  • He J; The Jackson Laboratory, Bar Harbor, ME, USA.
  • Macandog AD; Department of Molecular & Biomedical Sciences, University of Maine, Orono, ME, 04469, USA.
  • Nabinejad A; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Nava Lauson CB; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Quinte' A; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Bertalot G; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Petz WL; Department of Pathology, APSS Trento Hospital & Health Care, Trento, Italy.
  • Ravenda SP; Digestive Surgery Division, European Institute of Oncology-IRCCS, Milan, Italy.
  • Licursi V; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology-IRCCS, Milan, Italy.
  • Paci P; Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR) of Italy, Rome, Italy.
  • Rasponi M; Department of Computer, Control and Management Engineering, Sapienza - University of Rome, Rome, Italy.
  • Rotta L; Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.
  • Fazio N; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Ren G; Digestive Surgery Division, European Institute of Oncology-IRCCS, Milan, Italy.
  • Fumagalli-Romario U; The Jackson Laboratory, Bar Harbor, ME, USA.
  • Schaefer MH; Digestive Surgery Division, European Institute of Oncology-IRCCS, Milan, Italy.
  • Campaner S; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy.
  • Lugli E; Center for Genomic Science of IIT, CGS@SEMM (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), Milano, Italy.
  • Nezi L; Laboratory of Translational Immunology, IRCCS- Humanitas Research Hospital-, Milan, Italy.
  • Manzo T; Department of Experimental Oncology, European Institute of Oncology- IRCCS, Milano, Italy. luigi.nezi@ieo.it.
Nat Commun ; 13(1): 6752, 2022 11 08.
Article in En | MEDLINE | ID: mdl-36347862
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / CD8-Positive T-Lymphocytes Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Type: Article Affiliation country: Italy
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / CD8-Positive T-Lymphocytes Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Type: Article Affiliation country: Italy