Host-directed therapies for malaria: possible applications and lessons from other indications.
Curr Opin Microbiol
; 71: 102228, 2023 02.
Article
in En
| MEDLINE
| ID: mdl-36395572
ABSTRACT
Host-directed therapies (HDT) are rapidly advancing as a new and clinically relevant strategy to treat infectious disease. The application of HDT can be broadly used to (i) inhibit host factors essential for pathogen development, including host protein kinases, (ii) control detrimental immune signalling, resulting from excessive release of cytokines, chemokines and extracellular vesicles and (iii) strengthen host defence mechanisms, such as tight junctions in the endothelium. For malaria and other eukaryotic parasite-causing diseases, HDTs could provide a novel avenue to combat the growing resistance seen across all antimicrobials and provide protection against the severe forms of disease through modulation of the host immune response.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Malaria
/
Anti-Infective Agents
Limits:
Humans
Language:
En
Journal:
Curr Opin Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2023
Type:
Article