Intestinal atresia and necrotizing enterocolitis: Embryology and anatomy.
Semin Pediatr Surg
; 31(6): 151234, 2022 Dec.
Article
in En
| MEDLINE
| ID: mdl-36417784
ABSTRACT
The primitive gut originates at week 3 of gestation from the endoderm, with posterior incorporation of the remaining embryo layers. Wnt, Notch and TLR4 pathways have been shown to play central roles in the correct development of the intestine. The classical hypothesis for intestinal atresia development consists of failure in bowel recanalization or a vascular accident with secondary bowel reabsorption. These have been challenged due to the high frequency of associated malformations, and furthermore, with the discovery of molecular pathways and genes involved in bowel formation and correlated defects producing atresia. Necrotizing enterocolitis (NEC) has a multifactorial pathogenesis with prematurity being the most important risk factor; therefore, bowel immaturity plays a central role in NEC. Some of the same molecular pathways involved in gut maturation have been found to correlate with the predisposition of the immature bowel to develop the pathological findings seen in NEC.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Enterocolitis, Necrotizing
/
Infant, Newborn, Diseases
/
Intestinal Atresia
Limits:
Humans
/
Newborn
Language:
En
Journal:
Semin Pediatr Surg
Journal subject:
PEDIATRIA
Year:
2022
Type:
Article