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Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia.
Aramburu, Iker Valle; Hoving, Dennis; Vernardis, Spyros I; Tin, Martha C F; Ioannou, Marianna; Temkin, Mia I; De Vasconcelos, Nathalia M; Demichev, Vadim; Helbig, Elisa Theresa; Lippert, Lena; Stahl, Klaus; White, Matthew; Radbruch, Helena; Ihlow, Jana; Horst, David; Chiesa, Scott T; Deanfield, John E; David, Sascha; Bode, Christian; Kurth, Florian; Ralser, Markus; Papayannopoulos, Venizelos.
Affiliation
  • Aramburu IV; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK.
  • Hoving D; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK.
  • Vernardis SI; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK.
  • Tin MCF; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK.
  • Ioannou M; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK.
  • Temkin MI; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK.
  • De Vasconcelos NM; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK.
  • Demichev V; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK.
  • Helbig ET; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.
  • Lippert L; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.
  • Stahl K; Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany.
  • White M; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK.
  • Radbruch H; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neuropathology, Charitéplatz 1, 10117 Berlin, Germany.
  • Ihlow J; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pathology, Charitéplatz 1, 10117 Berlin, Germany.
  • Horst D; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pathology, Charitéplatz 1, 10117 Berlin, Germany.
  • Chiesa ST; Institute of Cardiovascular Science, University College London, London, UK.
  • Deanfield JE; Institute of Cardiovascular Science, University College London, London, UK.
  • David S; Institute for Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland.
  • Bode C; Department of Anaesthesiology and Critical Care, University Hospital Bonn, Bonn, Germany.
  • Kurth F; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.
  • Ralser M; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK; Charité - Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
  • Papayannopoulos V; The Francis Crick Institute, Antimicrobial Defence Laboratory, London, UK. Electronic address: veni.p@crick.ac.uk.
Immunity ; 55(12): 2436-2453.e5, 2022 12 13.
Article in En | MEDLINE | ID: mdl-36462503
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sepsis / COVID-19 Type of study: Prognostic_studies Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2022 Type: Article Affiliation country: United kingdom
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sepsis / COVID-19 Type of study: Prognostic_studies Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2022 Type: Article Affiliation country: United kingdom