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Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion-symptom mapping study in 3525 memory clinic patients.
Coenen, Mirthe; Kuijf, Hugo J; Huenges Wajer, Irene M C; Duering, Marco; Wolters, Frank J; Fletcher, Evan F; Maillard, Pauline M; Barkhof, Frederik; Barnes, Josephine; Benke, Thomas; Boomsma, Jooske M F; Chen, Christopher P L H; Dal-Bianco, Peter; Dewenter, Anna; Enzinger, Christian; Ewers, Michael; Exalto, Lieza G; Franzmeier, Nicolai; Groeneveld, Onno; Hilal, Saima; Hofer, Edith; Koek, Dineke L; Maier, Andrea B; McCreary, Cheryl R; Padilla, Catarina S; Papma, Janne M; Paterson, Ross W; Pijnenburg, Yolande A L; Rubinski, Anna; Schmidt, Reinhold; Schott, Jonathan M; Slattery, Catherine F; Smith, Eric E; Steketee, Rebecca M E; Sudre, Carole H; van den Berg, Esther; van der Flier, Wiesje M; Venketasubramanian, Narayanaswamy; Vernooij, Meike W; Xin, Xu; DeCarli, Charles; Biessels, Geert Jan; Biesbroek, J Matthijs.
Affiliation
  • Coenen M; Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
  • Kuijf HJ; Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Huenges Wajer IMC; Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
  • Duering M; Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands.
  • Wolters FJ; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Fletcher EF; Medical Image Analysis Center (MIAC) and Department of Biomedical Engineering, University of Basel, Basel, Switzerland.
  • Maillard PM; Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  • Barkhof F; Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  • Barnes J; Department of Neurology, University of California at Davis, Davis, California, USA.
  • Benke T; Department of Neurology, University of California at Davis, Davis, California, USA.
  • Boomsma JMF; Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
  • Chen CPLH; Radiology & Nuclear Medicine, Amsterdam UMC, location Vrije Universiteit, Amsterdam, The Netherlands.
  • Dal-Bianco P; UCL Institute of Neurology, London, UK.
  • Dewenter A; Dementia Research Centre, UCL Queen Square Institute of Neurology, UCL, London, UK.
  • Enzinger C; Clinic of Neurology, Medical University Innsbruck, Innsbruck, Austria.
  • Ewers M; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
  • Exalto LG; Department of Pharmacology, National University of Singapore, Singapore, Singapore.
  • Franzmeier N; Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.
  • Groeneveld O; Department of Neurology, Medical University Vienna, Vienna, Austria.
  • Hilal S; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Hofer E; Division of General Neurology, Department of Neurology, Medical University Graz, Graz, Austria.
  • Koek DL; Division of Neuroradiology, Interventional and Vascular Radiology, Department of Radiology, Medical University of Graz, Graz, Austria.
  • Maier AB; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • McCreary CR; Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
  • Padilla CS; Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Papma JM; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Paterson RW; Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
  • Pijnenburg YAL; Department of Neurology, Isala MS Centre, Isala Hospital, Meppel, The Netherlands.
  • Rubinski A; Department of Pharmacology, National University of Singapore, Singapore, Singapore.
  • Schmidt R; Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.
  • Schott JM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
  • Slattery CF; Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
  • Smith EE; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
  • Steketee RME; Department of Geriatric Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Sudre CH; Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.
  • van den Berg E; Department of Medicine, National University of Singapore, Singapore, Singapore.
  • van der Flier WM; Department of Clinical Neurosciences and Radiology and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
  • Venketasubramanian N; Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
  • Vernooij MW; Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  • Xin X; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  • DeCarli C; Dementia Research Centre, UCL Queen Square Institute of Neurology, UCL, London, UK.
  • Biessels GJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
  • Biesbroek JM; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Alzheimers Dement ; 19(6): 2420-2432, 2023 06.
Article in En | MEDLINE | ID: mdl-36504357
ABSTRACT

INTRODUCTION:

Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study.

METHODS:

Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel-based and region of interest tract-based analyses.

RESULTS:

WMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus were significantly related to domain-specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains.

DISCUSSION:

The data show that the impact of WMH on cognition is location-dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment. HIGHLIGHTS We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cognitive Dysfunction / White Matter Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Alzheimers Dement Year: 2023 Type: Article Affiliation country: Netherlands
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cognitive Dysfunction / White Matter Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Alzheimers Dement Year: 2023 Type: Article Affiliation country: Netherlands