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Plasma thymic stromal lymphopoietin (TSLP) in adults with non-severe asthma: the EGEA study.
Ibrahim, Bakari; Achour, Djamal; Zerimech, Farid; de Nadai, Patricia; Siroux, Valerie; Tsicopoulos, Anne; Matran, Régis; Granger, Vanessa; Nadif, Rachel.
Affiliation
  • Ibrahim B; Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Paris, France bakari.ibrahim@inserm.fr.
  • Achour D; Université Lille, CHU Lille, Institut Pasteur de Lille, EA 4483, IMPECS, Lille, France.
  • Zerimech F; Université Lille, CHU Lille, Institut Pasteur de Lille, EA 4483, IMPECS, Lille, France.
  • de Nadai P; Université Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
  • Siroux V; Université Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, Grenoble, France.
  • Tsicopoulos A; Université Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France.
  • Matran R; Université Lille, CHU Lille, Institut Pasteur de Lille, ULR 4483, Lille, France.
  • Granger V; Inserm, Inflammation microbiome immunosurveillance, Université Paris-Saclay, Paris, France.
  • Nadif R; UF autoimmunité Hypersensibilités et Biothérapies, APHP, HUPNVS, Hôpital Bichat, Paris, France.
Thorax ; 78(2): 207-210, 2023 02.
Article in En | MEDLINE | ID: mdl-36517245
ABSTRACT
Thymic stromal lymphopoietin (TSLP), a cytokine involved in severe asthma treatment, was never studied in non-severe asthma.Among 969 adults from a large epidemiological study, cross-sectional analyses showed that plasma TSLP levels were associated with increased age and BMI, male sex, smoking and high TSLP levels (one IQR increase) with current asthma and poor lung function. High TSLP levels were also associated with persistence of asthma attacks (aOR=2.14 (95% CI 1.23 to 3.72)) and dyspnoea (aOR=2.71 (95% CI 1.39 to 5.28)) 10 years later.Our results suggest that TSLP could be a cytokine of interest in non-severe asthma, and its determinants of circulating levels could be considered in asthma management.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Thymic Stromal Lymphopoietin Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Humans / Male Language: En Journal: Thorax Year: 2023 Type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Thymic Stromal Lymphopoietin Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Humans / Male Language: En Journal: Thorax Year: 2023 Type: Article Affiliation country: France