Accuracy of a Risk Alert Threshold for ICU Hypoglycemia: Retrospective Analysis of Alert Performance and Association With Clinical Deterioration Events.
Crit Care Med
; 51(1): 136-140, 2023 01 01.
Article
in En
| MEDLINE
| ID: mdl-36519987
ABSTRACT
OBJECTIVES:
To quantify the accuracy of and clinical events associated with a risk alert threshold for impending hypoglycemia during ICU admissions.DESIGN:
Retrospective electronic health record review of clinical events occurring greater than or equal to 1 and less than or equal to 12 hours after the hypoglycemia risk alert threshold was met.SETTING:
Adult ICU admissions from June 2020 through April 2021 at the University of Virginia Medical Center. PATIENTS Three hundred forty-two critically ill adults that were 63.5% male with median age 60.8 years, median weight 79.1 kg, and median body mass index of 27.5 kg/m2.INTERVENTIONS:
Real-world testing of our validated predictive model as a clinical decision support tool for ICU hypoglycemia. MEASUREMENTS AND MAINRESULTS:
We retrospectively reviewed 350 hypothetical alerts that met inclusion criteria for analysis. The alerts correctly predicted 48 cases of level 1 hypoglycemia that occurred greater than or equal to 1 and less than or equal to 12 hours after the alert threshold was met (positive predictive value = 13.7%). Twenty-one of these 48 cases (43.8%) involved level 2 hypoglycemia. Notably, three myocardial infarctions, one medical emergency team call, 19 deaths, and 20 arrhythmias occurred greater than or equal to 1 and less than or equal to 12 hours after an alert threshold was met.CONCLUSIONS:
Alerts generated by a validated ICU hypoglycemia prediction model had a positive predictive value of 13.7% for real-world hypoglycemia events. This proof-of-concept result suggests that the predictive model offers clinical value, but further prospective testing is needed to confirm this.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Decision Support Systems, Clinical
/
Clinical Deterioration
/
Hypoglycemia
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Crit Care Med
Year:
2023
Type:
Article
Affiliation country:
Vatican City