Global insights into the fine tuning of human A<sub>2A</sub>AR conformational dynamics in a ternary complex with an engineered G protein viewed by NMR.

Ferré, Guillaume; Anazia, Kara; Silva, Larissa O; Thakur, Naveen; Ray, Arka P; Eddy, Matthew T

Global insights into the fine tuning of human A_2AAR conformational dynamics in a ternary complex with an engineered G protein viewed by NMR.

Ferré, Guillaume; Anazia, Kara; Silva, Larissa O; Thakur, Naveen; Ray, Arka P; Eddy, Matthew T.

Affiliation

Ferré G; Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Anazia K; Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Silva LO; Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Thakur N; Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Ray AP; Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Eddy MT; Department of Chemistry, University of Florida, Gainesville, FL 32611, USA. Electronic address: matthew.eddy@chem.ufl.edu.

Cell Rep ; 41(12): 111844, 2022 12 20.

Article in En | MEDLINE | ID: mdl-36543140

Subject(s)

GTP-Binding Proteins; Receptors, G-Protein-Coupled; Humans; GTP-Binding Proteins/metabolism; Molecular Conformation; Receptors, G-Protein-Coupled/metabolism; Signal Transduction/physiology; Magnetic Resonance Spectroscopy; Ligands; Receptor, Adenosine A2A/metabolism; Protein Conformation

Key words

A(2A) adenosine receptor; CP: Molecular biology; G(s) protein; GPCR; NMR; biophysics; mini-G(s); signaling complexes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: GTP-Binding Proteins / Receptors, G-Protein-Coupled Limits: Humans Language: En Journal: Cell Rep Year: 2022 Type: Article Affiliation country: United States

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