Integrating Systematic Reviews into Supportive Care Trial Design: The Rethinking Clinical Trials (REaCT) Program.
Curr Oncol
; 29(12): 9550-9559, 2022 12 05.
Article
in En
| MEDLINE
| ID: mdl-36547164
ABSTRACT
PURPOSE:
To review the successes and challenges of integrating systematic reviews (SRs) into the Rethinking Clinical Trials (REaCT) Program.METHODS:
All REaCT program SRs were evaluated and descriptive summaries presented.RESULTS:
Twenty-two SRs have been performed evaluating standard of care interventions for the management of breast cancer (n = 15), all tumour sites (n = 4), breast and prostate cancers (n = 2), and prostate cancer (n = 1). The majority of SRs were related to supportive care (n = 14) and survivorship (n = 5) interventions and most (19/22, 86%) confirmed the existence of uncertainty relating to the clinical question addressed in the SR. Most SRs (15/22, 68%) provided specific recommendations for future studies and results were incorporated into peer-reviewed grant applications (n = 6) and clinical trial design (n = 12). In 12/22 of the SRs, the first author was a trainee. All SRs followed PRISMA guidelines.CONCLUSION:
SRs are important for identifying and confirming clinical equipoise and designing trials. SRs provide an excellent opportunity for trainees to participate in research.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Research Design
/
Breast Neoplasms
Type of study:
Guideline
/
Prognostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Curr Oncol
Year:
2022
Type:
Article
Affiliation country:
Canada