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Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ-focal adhesion kinase signaling circuitry.
Arang, Nadia; Lubrano, Simone; Rigiracciolo, Damiano Cosimo; Nachmanson, Daniela; Lippman, Scott M; Mali, Prashant; Harismendy, Olivier; Gutkind, J Silvio.
Affiliation
  • Arang N; University of California San Diego, Moores Cancer Center, La Jolla, California, USA; University of California San Diego, Biomedical Sciences Graduate Program, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla, California, USA.
  • Lubrano S; University of California San Diego, Moores Cancer Center, La Jolla, California, USA; Department of Pharmacy, University of Pisa, Pisa, Italy.
  • Rigiracciolo DC; University of California San Diego, Moores Cancer Center, La Jolla, California, USA.
  • Nachmanson D; University of California San Diego, Bioinformatics and Systems Biology Graduate Program, La Jolla, California, USA.
  • Lippman SM; University of California San Diego, Moores Cancer Center, La Jolla, California, USA.
  • Mali P; Department of Bioengineering, University of California San Diego, La Jolla, California, USA.
  • Harismendy O; University of California San Diego, Moores Cancer Center, La Jolla, California, USA; Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Gutkind JS; University of California San Diego, Moores Cancer Center, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla, California, USA. Electronic address: sgutkind@health.ucsd.edu.
J Biol Chem ; 299(2): 102866, 2023 02.
Article in En | MEDLINE | ID: mdl-36596361
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositol 3-Kinases / GTP-Binding Protein alpha Subunits, Gq-G11 / Proto-Oncogene Proteins c-akt / Focal Adhesion Protein-Tyrosine Kinases / Carcinogenesis Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositol 3-Kinases / GTP-Binding Protein alpha Subunits, Gq-G11 / Proto-Oncogene Proteins c-akt / Focal Adhesion Protein-Tyrosine Kinases / Carcinogenesis Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2023 Type: Article Affiliation country: United States