Identification of Novel Genetic Risk Factors for Focal Segmental Glomerulosclerosis in Children: Results From the Chronic Kidney Disease in Children (CKiD) Cohort.

Durand, Axelle; Winkler, Cheryl A; Vince, Nicolas; Douillard, Venceslas; Geffard, Estelle; Binns-Roemer, Elizabeth; Ng, Derek K; Gourraud, Pierre-Antoine; Reidy, Kimberley; Warady, Bradley; Furth, Susan; Kopp, Jeffrey B; Kaskel, Frederick J; Limou, Sophie

Durand, Axelle; Winkler, Cheryl A; Vince, Nicolas; Douillard, Venceslas; Geffard, Estelle; Binns-Roemer, Elizabeth; Ng, Derek K; Gourraud, Pierre-Antoine; Reidy, Kimberley; Warady, Bradley; Furth, Susan; Kopp, Jeffrey B; Kaskel, Frederick J; Limou, Sophie.

Affiliation

Durand A; Center for Research in Transplantation and Translational Immunology (UMR 1064), Nantes Université, Ecole Centrale Nantes, CHU Nantes, INSERM, F-44000 Nantes, France.
Winkler CA; Basic Research Laboratory, Center for Cancer Research, Frederick National Laboratory, National Cancer Institute, Frederick, Maryland.
Vince N; Center for Research in Transplantation and Translational Immunology (UMR 1064), Nantes Université, Ecole Centrale Nantes, CHU Nantes, INSERM, F-44000 Nantes, France.
Douillard V; Center for Research in Transplantation and Translational Immunology (UMR 1064), Nantes Université, Ecole Centrale Nantes, CHU Nantes, INSERM, F-44000 Nantes, France.
Geffard E; Center for Research in Transplantation and Translational Immunology (UMR 1064), Nantes Université, Ecole Centrale Nantes, CHU Nantes, INSERM, F-44000 Nantes, France.
Binns-Roemer E; Basic Research Laboratory, Center for Cancer Research, Frederick National Laboratory, National Cancer Institute, Frederick, Maryland.
Ng DK; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Gourraud PA; Center for Research in Transplantation and Translational Immunology (UMR 1064), Nantes Université, Ecole Centrale Nantes, CHU Nantes, INSERM, F-44000 Nantes, France.
Reidy K; Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.
Warady B; Children's Mercy Kansas City, Kansas City, Missouri.
Furth S; Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania.
Kopp JB; Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Kaskel FJ; Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.
Limou S; Center for Research in Transplantation and Translational Immunology (UMR 1064), Nantes Université, Ecole Centrale Nantes, CHU Nantes, INSERM, F-44000 Nantes, France. Electronic address: sophie.limou@univ-nantes.fr.

Am J Kidney Dis ; 81(6): 635-646.e1, 2023 06.

Article in En | MEDLINE | ID: mdl-36623684

Subject(s)

Glomerulosclerosis, Focal Segmental; Renal Insufficiency, Chronic; Adult; Humans; Child; Glomerulosclerosis, Focal Segmental/pathology; Apolipoprotein L1/genetics; Genome-Wide Association Study; Prospective Studies; Risk Factors; Renal Insufficiency, Chronic/epidemiology; Renal Insufficiency, Chronic/genetics

Key words

ALMS1; APOL1 G1; African American; CCDC7; CDH12; DNAH6; FGFR4; GRB2; HLA; KCNK6; SCNN1G; children; chronic kidney disease (CKD); focal segmental glomerulosclerosis (FSGS); gene-set enrichment analysis; genetic risk marker; genome-wide association study (GWAS); pediatric; single-nucleotide variant (SNV)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glomerulosclerosis, Focal Segmental / Renal Insufficiency, Chronic Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Child / Humans Language: En Journal: Am J Kidney Dis Year: 2023 Type: Article Affiliation country: France

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