Is the antiparasitic drug ivermectin a suitable candidate for the treatment of epilepsy?

Löscher, Wolfgang

Löscher, Wolfgang.

Affiliation

Löscher W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany.

Epilepsia ; 64(3): 553-566, 2023 03.

Article in En | MEDLINE | ID: mdl-36645121

Subject(s)

Anticonvulsants; Antiparasitic Agents; Epilepsy; Ivermectin; Antiparasitic Agents/chemistry; Antiparasitic Agents/pharmacokinetics; Antiparasitic Agents/therapeutic use; Antiparasitic Agents/toxicity; Ivermectin/chemistry; Ivermectin/pharmacokinetics; Ivermectin/therapeutic use; Ivermectin/toxicity; Epilepsy/drug therapy; Humans; Cysteine Loop Ligand-Gated Ion Channel Receptors/agonists; Anticonvulsants/chemistry; Anticonvulsants/pharmacokinetics; Anticonvulsants/therapeutic use; Anticonvulsants/toxicity; Brain/metabolism; Animals; Mice

Key words

GABA receptors; P-glycoprotein; blood-brain barrier; onchocerciasis; seizures

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ivermectin / Epilepsy / Anticonvulsants / Antiparasitic Agents Limits: Animals / Humans Language: En Journal: Epilepsia Year: 2023 Type: Article Affiliation country: Germany

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