Deep gray matter substructure volumes and depressive symptoms in a large multiple sclerosis cohort.
Mult Scler
; 29(7): 809-818, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-36691798
ABSTRACT
BACKGROUND:
Consistent findings on underlying brain features or specific structural atrophy patterns contributing to depression in multiple sclerosis (MS) are limited.OBJECTIVE:
To investigate how deep gray matter (DGM) features predict depressive symptom trajectories in MS patients.METHODS:
We used data from the MS Partners Advancing Technology and Health Solutions (MS PATHS) network in which standardized patient information and outcomes are collected. We performed whole-brain segmentation using SLANT-CRUISE. We assessed if DGM structures were associated with elevated depressive symptoms over follow-up and with depressive symptom phenotypes.RESULTS:
We included 3844 participants (average age 46.05 ± 11.83 years; 72.7% female) of whom 1905 (49.5%) experienced ⩾1 periods of elevated depressive symptoms over 2.6 ± 0.9 years mean follow-up. Higher caudate, putamen, accumbens, ventral diencephalon, thalamus, and amygdala volumes were associated with lower odds of elevated depressive symptoms over follow-up (odds ratio (OR) range per 1 SD (standard deviation) increase in volume 0.88-0.94). For example, a 1 SD increase in accumbens or caudate volume was associated with 12% or 10% respective lower odds of having a period of elevated depressive symptoms over follow-up (for accumbens OR 0.88; 95% confidence interval (CI) 0.83-0.93; p < 0.001; for caudate OR 0.90; 95% CI 0.85-0.96; p = 0.003).CONCLUSION:
Lower DGM volumes were associated with depressive symptom trajectories in MS.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Multiple Sclerosis
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2023
Type:
Article
Affiliation country:
United States