Deletion of the Transcriptional Coactivator HCF-1 <i>In Vivo</i> Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation.

Arbuckle, Jesse H; Vogel, Jodi L; Efstathiou, Stacey; Kristie, Thomas M

Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation.

Arbuckle, Jesse H; Vogel, Jodi L; Efstathiou, Stacey; Kristie, Thomas M.

Affiliation

Arbuckle JH; Laboratory of Viral Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Vogel JL; Laboratory of Viral Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Efstathiou S; Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Kristie TM; Laboratory of Viral Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

mBio ; 14(1): e0354222, 2023 02 28.

Article in En | MEDLINE | ID: mdl-36692302

Subject(s)

Herpes Simplex; Herpesvirus 1, Human; Animals; Mice; Gene Expression Regulation, Viral; Herpesvirus 1, Human/physiology; Heterochromatin; Transcription Factors/metabolism; Transcription, Genetic; Virus Latency/physiology

Key words

HCF-1; HSV reactivation; herpes simplex virus; latency; viral chromatin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Herpesvirus 1, Human / Herpes Simplex Type of study: Prognostic_studies Limits: Animals Language: En Journal: MBio Year: 2023 Type: Article Affiliation country: United States

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