Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective.
Mem Inst Oswaldo Cruz
; 117: e220109, 2023.
Article
in En
| MEDLINE
| ID: mdl-36700579
ABSTRACT
BACKGROUND:
The human immunodeficiency virus type 1, F1 sub-subtype (HIV-1 F1) circulates in three continents Africa, Europe, and South America. In Brazil, this sub-subtype co-circulates with subtypes B and C and several recombinant forms, mainly BF1 variants.OBJECTIVES:
This study aimed to reconstruct the dynamic history of HIV-1 F1 in Brazil.METHODS:
HIV-1 near full-length genome and pol gene nucleotide sequences available in public databases were assembled in two datasets (POL671 and NFLG53) to cover the largest number of F1 sub-subtype sequences. Phylodynamic and temporal analyses were performed.FINDINGS:
Two main strains of the F1 sub-subtype are circulating worldwide. The first (F1.I) was found among Brazilian samples (75%) and the second (F1.II) among Romanian (62%) and other European and African isolates. The F1 subtype epidemic in Brazil originated from a single entry into the country around 1970. This ancestral sample is related to samples isolated in European countries (France, Finland, and Belgium), which are possibly of African origin. Moreover, further migration (1998 CI 1994-2003) of strains from Brazil to Europe (Spain and the UK) was observed. Interestingly, all different recombinant BF patterns found, even those from outside Brazil, present the same F1 lineage (F1.I) as an ancestor, which could be related to the acquisition of adaptive advantages for the recombinant progenies. MAINCONCLUSIONS:
These findings are important for the understanding of the origin and dynamics of the F1 sub-subtype and a consequent better and greater understanding of the HIV-1 F1 and BF epidemic that still spreads from Brazil to other countries.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phylogeny
/
HIV-1
Limits:
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Mem Inst Oswaldo Cruz
Year:
2023
Type:
Article
Affiliation country:
Brazil