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Microglia C-lectin/selectin' neurons to eat.
Jiang, Yike; Shinohara, Mari L.
Affiliation
  • Jiang Y; Department of Immunology, Duke University School of Medicine, Durham, NC, USA; Division of Pediatric Rheumatology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
  • Shinohara ML; Department of Immunology, Duke University School of Medicine, Durham, NC, USA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA. Electronic address: mari.shinohara@duke.edu.
Immunity ; 56(2): 227-229, 2023 02 14.
Article in En | MEDLINE | ID: mdl-36792566
ABSTRACT
ß-glucosylceramide (ß-GlcCer) accumulates in Gaucher disease, but how ß-GlcCer, a Mincle ligand, causes characteristic neuroinflammation and neuronopathy is poorly understood. In this issue of Immunity, Shimizu et al. reveal that Mincle-dependent activation of microglia led to phagocytosis of neurons and neurologic symptoms.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microglia / Lectins Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microglia / Lectins Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2023 Type: Article Affiliation country: United States