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The Use of Neural Stem Cells-Derived Exosomes to Prevent Late Radiation-Induced Cognitive Impairments in Mice.
Ratushnyak, M G; Zhirnik, A S; Smirnova, O D; Semochkina, Yu P; Parfenova, A A; Goryunov, K V; Silachev, D N; Moskaleva, E Yu.
Affiliation
  • Ratushnyak MG; National Research Center "Kurchatov Institute", Moscow, Russia. ratushnyak_marya@mail.ru.
  • Zhirnik AS; National Research Center "Kurchatov Institute", Moscow, Russia.
  • Smirnova OD; National Research Center "Kurchatov Institute", Moscow, Russia.
  • Semochkina YP; National Research Center "Kurchatov Institute", Moscow, Russia.
  • Parfenova AA; National Research Center "Kurchatov Institute", Moscow, Russia.
  • Goryunov KV; V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Silachev DN; V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Moskaleva EY; National Research Center "Kurchatov Institute", Moscow, Russia.
Bull Exp Biol Med ; 174(4): 571-577, 2023 Feb.
Article in En | MEDLINE | ID: mdl-36894818
ABSTRACT
We studied the effect of intranasal administration of neural stem cell (NSC)-derived exosomes on behavior and cognitive functions of mice in the late period after head irradiation in a dose of 8 Gy. The used exosomes had specific markers (CD9+/CD63+, 99.5%; TSG101+, 98.4%) and mean size 105.7±8.8 nm according to dynamic light scattering data and 119.0±12.4 nm according to nanoparticle tracking analysis (NTA). Exosome suspension (2×1012 particles/ml according to NTA measurements) was administered intranasally for 4 weeks starting from 48 h after irradiation in a volume of 5 µl/nostril (2×1010 exosomes/mouse). It was shown that intranasal administration of mouse NSC-derived exosomes prevented delayed radiation-induced behavioral changes and recognition memory impairments in mice after head irradiation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Exosomes / Neural Stem Cells / Cognitive Dysfunction Type of study: Etiology_studies Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2023 Type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Exosomes / Neural Stem Cells / Cognitive Dysfunction Type of study: Etiology_studies Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2023 Type: Article Affiliation country: RUSSIA