Tebentafusp: a first-in-class treatment for metastatic uveal melanoma.
Ther Adv Med Oncol
; 15: 17588359231160140, 2023.
Article
in En
| MEDLINE
| ID: mdl-36970111
ABSTRACT
Tebentafusp is a first-in-class immunotherapy agent that comprises an engineered T-cell receptor targeting a gp100 epitope presented by human leukocyte antigen-A*0201 cells, fused to an anti-CD3 single-chain variable fragment. Tebentafusp is both the first bispecific T-cell engager to show efficacy in the treatment of advanced solid cancer and the first anti-cancer treatment to demonstrate an overall survival benefit in patients with uveal melanoma (UM). This review article will focus on the clinical development of tebentafusp, the mechanism of action and resultant evolution of the management of advanced UM.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Ther Adv Med Oncol
Year:
2023
Type:
Article
Affiliation country:
United kingdom