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Hypoxia-Induced Kidney Injury in Newborn Rats.
Chu, Yi-Ting; Chen, Bo-Hau; Chen, Hsin-Hung; Lee, Jui-Chen; Kuo, Tzu-Jiun; Chiu, Hsiang-Chin; Lu, Wen-Hsien.
Affiliation
  • Chu YT; Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.
  • Chen BH; Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan 32551, Taiwan.
  • Chen HH; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.
  • Lee JC; Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.
  • Kuo TJ; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.
  • Chiu HC; Department of Pediatrics, Pingtung Veterans General Hospital, Pingtung 91245, Taiwan.
  • Lu WH; Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.
Toxics ; 11(3)2023 Mar 11.
Article in En | MEDLINE | ID: mdl-36977025
ABSTRACT
Exposure to hypoxia during the early postnatal period can have adverse effects on vital organs. Neonatal Sprague-Dawley rats housed in a hypoxic chamber were compared to those in a normoxic chamber from postnatal days 0 to 7. Arterial blood was collected to evaluate renal function and hypoxia. Kidney morphology and fibrosis were evaluated using staining methods and immunoblotting. In the kidneys of the hypoxic group, protein expressions of hypoxia-inducible factor-1 were higher than those in the normoxic group. Hypoxic rats had higher levels of hematocrit, serum creatinine, and lactate than normoxic rats. Body weight was reduced, and protein loss of kidney tissue was observed in hypoxic rats compared to normoxic rats. Histologically, hypoxic rats showed glomerular atrophy and tubular injury. Renal fibrosis with collagen fiber deposition was observed in the hypoxic group. The expression of nicotinamide adenine dinucleotide phosphate oxidases was enhanced in the kidneys of hypoxic rats. Proteins involved in apoptosis were upregulated in the kidneys of hypoxic rats. An increase in the expression of pro-inflammatory cytokines was also observed in the kidneys of hypoxic rats. Hypoxic kidney injury in neonatal rats was associated with oxidative stress, inflammation, apoptosis, and fibrosis.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Toxics Year: 2023 Type: Article Affiliation country: Taiwan

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Toxics Year: 2023 Type: Article Affiliation country: Taiwan