Effect of central noradrenaline depletion on corticosterone levels and gastric ulcerations in rats.
Brain Res
; 368(2): 256-61, 1986 Mar 19.
Article
in En
| MEDLINE
| ID: mdl-3697726
ABSTRACT
Effects of central noradrenergic depletion on the stress responses of rats were explored using the new selective neurotoxin (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)). Noradrenergic depletion using DSP-4 was followed by a reduction in basal corticosterone levels after 7 days. Three weeks after DSP-4 treatment, animals exhibited less severe and fewer gastric ulcerations than control animals following 23 h immobilization stress, but stress levels of corticosterone were similar for the two groups. No differences could be found in the peripheral gastric levels of noradrenaline between experimental and control animals, while central noradrenaline was reduced to approximately 30% of control levels. The data support previous findings using other methods that central noradrenaline is an important factor in stress-induced gastric ulceration. The peripheral mechanisms for the protective effects of DSP-4 remain to be elucidated, and studies of these may cast light on the efferent pathways between the central nervous system and gastric mucosa which are involved in stress-induced gastric pathology.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Ulcer
/
Corticosterone
/
Norepinephrine
Limits:
Animals
Language:
En
Journal:
Brain Res
Year:
1986
Type:
Article