Structural mechanisms for regulation of GSDMB pore-forming activity.

Zhong, Xiu; Zeng, Huan; Zhou, Zhiwei; Su, Ya; Cheng, Hang; Hou, Yanjie; She, Yang; Feng, Na; Wang, Jia; Shao, Feng; Ding, Jingjin

Zhong, Xiu; Zeng, Huan; Zhou, Zhiwei; Su, Ya; Cheng, Hang; Hou, Yanjie; She, Yang; Feng, Na; Wang, Jia; Shao, Feng; Ding, Jingjin.

Affiliation

Zhong X; Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing, PR China.
Zeng H; National Institute of Biological Sciences, Beijing, PR China.
Zhou Z; National Institute of Biological Sciences, Beijing, PR China.
Su Y; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China.
Cheng H; University of Chinese Academy of Sciences, Beijing, PR China.
Hou Y; National Institute of Biological Sciences, Beijing, PR China.
She Y; Research Unit of Pyroptosis and Immunity, Chinese Academy of Medical Sciences and National Institute of Biological Sciences, Beijing, PR China.
Feng N; National Institute of Biological Sciences, Beijing, PR China.
Wang J; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, PR China.
Shao F; Shuimu BioSciences, Beijing, PR China.
Ding J; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China.

Nature ; 616(7957): 598-605, 2023 04.

Article in En | MEDLINE | ID: mdl-36991125

Subject(s)

Gasdermins; Pore Forming Cytotoxic Proteins; Animals; Humans; Mice; Cell Line, Tumor; Cryoelectron Microscopy; Crystallography, X-Ray; Gasdermins/chemistry; Gasdermins/genetics; Gasdermins/metabolism; Gasdermins/ultrastructure; Neoplasm Proteins/chemistry; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Neoplasm Proteins/ultrastructure; Pore Forming Cytotoxic Proteins/chemistry; Pore Forming Cytotoxic Proteins/genetics; Pore Forming Cytotoxic Proteins/metabolism; Pore Forming Cytotoxic Proteins/ultrastructure; Protein Isoforms/chemistry; Protein Isoforms/genetics; Protein Isoforms/metabolism; Protein Isoforms/ultrastructure; Pyroptosis; Shigella flexneri; Species Specificity; Alternative Splicing

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pore Forming Cytotoxic Proteins / Gasdermins Limits: Animals / Humans Language: En Journal: Nature Year: 2023 Type: Article

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