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Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder.
Baldelli, Luca; Pirazzini, Chiara; Sambati, Luisa; Ravaioli, Francesco; Gentilini, Davide; Calandra-Buonaura, Giovanna; Guaraldi, Pietro; Franceschi, Claudio; Cortelli, Pietro; Garagnani, Paolo; Bacalini, Maria Giulia; Provini, Federica.
Affiliation
  • Baldelli L; Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy.
  • Pirazzini C; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Sambati L; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
  • Ravaioli F; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Gentilini D; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
  • Calandra-Buonaura G; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
  • Guaraldi P; Bioinformatics and Statistical Genomics Unit, Istituto Auxologico Italiano IRCCS, Cusano Milanino, Milan, Italy.
  • Franceschi C; Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy.
  • Cortelli P; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Garagnani P; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Bacalini MG; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
  • Provini F; Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod, Russia.
NPJ Parkinsons Dis ; 9(1): 48, 2023 Mar 30.
Article in En | MEDLINE | ID: mdl-36997543
ABSTRACT
Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based controls. We found that iRBDs tended to be epigenetically older than controls, suggesting that accelerated aging characterizes prodromal neurodegeneration.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Parkinsons Dis Year: 2023 Type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Parkinsons Dis Year: 2023 Type: Article Affiliation country: Italy