Autoimmune glial fibrillary acidic protein astrocytopathy associated with breast cancer: a case report.
BMC Neurol
; 23(1): 145, 2023 Apr 04.
Article
in En
| MEDLINE
| ID: mdl-37016352
ABSTRACT
BACKGROUND:
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is an autoimmune inflammatory central nervous system disorder characterized by the detection of autoantibodies that recognize GFAP in CSF. The pathogenesis of GFAP-A is poorly understood. Some patients had a neoplasm detected and GFAP expressed by neoplasms is plausible as immunogen triggering paraneoplastic neurological autoimmunity. CASE PRESENTATION We report a case of 76-year-old female patient with GFAP-A complicated with breast cancer. She presented with altered consciousness, nuchal rigidity, speech disturbances, and weakness. Her clinical symptoms were improved by immunotherapy and cancer treatments. Immunohistochemical analysis showed that the restricted tumor expressed GFAP. The infiltration of CD3 + T cells were observed in the peritumoral and intratumoral areas. The most common infiltrating lymphocytes were CD8 + T cells. CD4 + T cells and CD20 + B cells were also observed in the predominant peritumoral area.CONCLUSIONS:
These results suggest that GFAP-A may occur in a paraneoplastic neurological syndrome associated with breast cancer.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Autoimmune Diseases of the Nervous System
Type of study:
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
BMC Neurol
Journal subject:
NEUROLOGIA
Year:
2023
Type:
Article
Affiliation country:
Japan