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Stereogenic-at-Cobalt(III) Complex Catalyzed Halocyclization of Alkynes: Enantioselective Access to Axially Chiral ortho-Halo-C2-indoles.
Yao, Chuan-Zhi; Xie, Zu-Kui; Wang, Jie-Yue; Zhang, Jia-Yu; Zhao, Zi-Yuan; Li, Qiankun; Yu, Jie.
Affiliation
  • Yao CZ; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
  • Xie ZK; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
  • Wang JY; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
  • Zhang JY; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
  • Zhao ZY; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
  • Li Q; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
  • Yu J; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
J Org Chem ; 88(9): 6146-6158, 2023 May 05.
Article in En | MEDLINE | ID: mdl-37022671
ABSTRACT
Here, we report an anionic stereogenic-at-cobalt(III) complex catalysis strategy for the enantioselective halocyclization of ortho-alkynylanilines using N-halosuccinimide (NXS) as the halogen source. This protocol provides a distinct atroposelective approach to access the axially chiral ortho-halo-C2-indole skeletons in excellent yields with good to high enantioselectivities (up to 99% yield, 991 er).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Org Chem Year: 2023 Type: Article Affiliation country: China
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Org Chem Year: 2023 Type: Article Affiliation country: China