Mineral, trace element, and toxic metal concentration in hair from dogs with idiopathic epilepsy compared to healthy controls.
J Vet Intern Med
; 37(3): 1100-1110, 2023.
Article
in En
| MEDLINE
| ID: mdl-37025060
ABSTRACT
BACKGROUND:
Altered trace element status is associated with epilepsy in humans and dogs with idiopathic epilepsy (IE).OBJECTIVES:
Compare hair element concentrations in epileptic and healthy dogs. ANIMALS Sixty-three dogs with IE (53 treated, 10 untreated) and 42 controls.METHODS:
Case-control study using ICP-MS to determine hair calcium, magnesium, phosphorus, sodium, potassium, iron, copper, manganese, zinc, selenium, chromium, lead, mercury, cadmium, arsenic, aluminum, and nickel concentration. Groups were compared using nonparametric tests. Results were controlled for diet, sex, age, and hair color using generalized linear mixed models.RESULTS:
Compared to healthy controls, dogs with IE had lower hair phosphorus (mean ± SD; IE 286.19 ± 69.62 µg/g, healthy 324.52 ± 58.69 µg/g; P = .001), higher hair copper (IE 10.97 ± 3.51 µg/g, healthy 8.41 ± 1.27 µg/g; P < .001), zinc (IE 158.25 ± 19.64 µg/g, healthy 144.76 ± 32.18 µg/g; P < .001), copper/zinc ratio (IE 0.07 ± 0.02, healthy 0.06 ± 0.01; P = .003), selenium (IE 1.65 ± 0.43 µg/g, healthy 0.94 ± 0.73 µg/g; P < .001), and arsenic (IE 0.40 ± 0.78 µg/g, healthy 0.05 ± 0.08 µg/g; P < .001). When comparing treated and untreated epileptic dogs with healthy dogs, the differences in phosphorus and selenium remained significant for both groups, whereas the differences in copper, zinc, and arsenic were significant only for treated dogs. Potassium bromide treatment was strongly associated with high hair arsenic (P = .000). CONCLUSIONS AND CLINICAL IMPORTANCE Altered trace element status could be involved in the pathophysiology of IE in dogs. Antiseizure drugs might affect trace element and arsenic metabolism.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arsenic
/
Selenium
/
Trace Elements
/
Dog Diseases
/
Epilepsy
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Vet Intern Med
Journal subject:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Year:
2023
Type:
Article
Affiliation country:
Finland