Cystatin C for kidney function assessment in patients with facioscapulohumeral muscular dystrophy.
Clin Chim Acta
; 544: 117328, 2023 Apr 01.
Article
in En
| MEDLINE
| ID: mdl-37031784
ABSTRACT
BACKGROUND AND AIMS:
Muscle mass (MM) impairment observed in facioscapulohumeral muscular dystrophy (FSHD) may bias estimated glomerular filtration rate (eGFR) based on creatinine (eGFRcreat). eGFR based on cystatin C (eGFRcys), produced by all nucleated cells, should be an interesting alternative. Main objectives were to compare eGFRcreat and eGRFcys for chronic kidney disease (CKD) staging and for annual eGFR evolution. Secondary objective was to analyse creatinine, cystatin C with measured MM. MATERIAL ANDMETHODS:
During 4 years, 159 FSHD patients having one or more creatinine and cystatin C measurements (total samples n = 379), with MM determination by bio-impedancemetry during their follow-up were included. eGFR were determined with CKD-Epi and EKFC equations.RESULTS:
On first examination samples, mean eGFRcys was significantly lower than mean eGFRcreat of 25.5 and 17.9 ml/min/1.73 m2 using CKD-Epi and EKFC equations, respectively. 53.5% (CKD-Epi) and 59.1% (EKFC) of agreement were obtained when using eGFRcys instead of eGFRcreat with reclassifications occurring mainly towards more severe stages. Age was correlated with cystatin C but not with creatinine, MM was correlated with creatinine but not with cystatin C. eGFR decreases > 1 ml/min/1.73 m2 were more important when using eGFRcys instead of eGFRcreat (CKD-Epi 37.5 vs 15.4%, p < 0.001; EKFC 34.6 vs 20.2%, p < 0.01).CONCLUSION:
Cystatin C which is independent of MM appears as a promising candidate biomarker for CKD diagnosis and follow-up in FSHD patient.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Muscular Dystrophy, Facioscapulohumeral
/
Renal Insufficiency, Chronic
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Clin Chim Acta
Year:
2023
Type:
Article
Affiliation country:
France