Molecular Networking Accelerated Discovery of Biflavonoid Alkaloids from Cephalotaxus sinensis.
Chem Biodivers
; 20(6): e202201197, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-37073748
ABSTRACT
Four undescribed biflavonoid alkaloids, sinenbiflavones A-D, were isolated from Cephalotaxus sinensis using a MS/MS-based molecular networking guided strategy. Their structures were elucidated by series of spectroscopic methods (HR-ESI-MS, UV, IR, 1D, and 2D NMR). Sinenbiflavones A-D are the first examples of amentoflavone-type (C-3'-C-8'') biflavonoid alkaloids. Meanwhile, sinenbiflavones B and D are the unique C-6-methylated amentoflavone-type biflavonoid alkaloids. Sinenbiflavone D showed weak SARS-CoV-2 3CLpro inhibitory activity with 43 % inhibition rate at 40â
µM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cephalotaxus
/
Biflavonoids
/
Alkaloids
/
COVID-19
Language:
En
Journal:
Chem Biodivers
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2023
Type:
Article