Dolichoectatic vertebrobasilar aneurysms: a systematic review and meta-analysis of management strategies and outcomes.
Neurosurg Focus
; 54(5): E9, 2023 05.
Article
in En
| MEDLINE
| ID: mdl-37127027
ABSTRACT
OBJECTIVE:
The aim of this study was to describe the efficacy, clinical outcomes, and complications of open cerebrovascular surgery, endovascular surgery, and conservative management of dolichoectatic vertebrobasilar aneurysms (DVBAs).METHODS:
Relevant articles were retrieved from PubMed, Scopus, Web of Science, and Cochrane databases according to PRISMA guidelines. A meta-analysis was conducted for clinical presentation, treatment protocols, and clinical outcomes-good (improved or stable clinical status) or poor (deteriorated clinical status or death)-and mortality rates.RESULTS:
The 9 identified articles described 41 cases (27.5%) of open cerebrovascular surgery, 61 endovascular procedures (40.9%), and 47 cases (31.5%) of conservative management for DVBAs. The total cohort had a good outcome rate of 51.9% (95% CI 28.3%-74.6%), a poor outcome rate of 45.5% (95% CI 23.0%-70.1%), and a mortality rate of 22.3% (95% CI 11.8%-38.0%). The treatment groups had comparable good clinical outcome rates (open cerebrovascular surgery group 24.7% [95% CI 2.9%-78.2%]; endovascular surgery group 69.0% [95% CI 28.7%-92.5%]; conservative management group 57.7% [95% CI 13.0%-92.5%]; p = 0.19) and poor outcome rates (open vascular surgery group 75.3% [95% CI 21.8%-97.1%]; endovascular surgery group 27.2% [95% CI 5.6%-0.70.2%]; conservative management group 39.9% [95% CI 9.1%-81.6%]; p = 0.15). The treatment groups also had comparable mortality rates (open vascular surgery group 39.5% [95% CI 11.4%-76.8%]; endovascular surgery group 15.8% [95% CI 4.4%-43.0%]; conservative management group 19.2% [95% CI 6.8%-43.5%]; p = 0.23).CONCLUSIONS:
The current study of DVBAs illustrated poor outcomes and high mortality rates regardless of the treatment modality. The subgroup analysis showed heterogeneity among the subgroups and advice for personalized management.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Intracranial Aneurysm
/
Endovascular Procedures
Type of study:
Guideline
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Neurosurg Focus
Journal subject:
NEUROCIRURGIA
Year:
2023
Type:
Article