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In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.
Dervovic, Dzana; Malik, Ahmad A; Chen, Edward L Y; Narimatsu, Masahiro; Adler, Nina; Afiuni-Zadeh, Somaieh; Krenbek, Dagmar; Martinez, Sebastien; Tsai, Ricky; Boucher, Jonathan; Berman, Jacob M; Teng, Katie; Ayyaz, Arshad; Lü, YiQing; Mbamalu, Geraldine; Loganathan, Sampath K; Lee, Jongbok; Zhang, Li; Guidos, Cynthia; Wrana, Jeffrey; Valipour, Arschang; Roux, Philippe P; Reimand, Jüri; Jackson, Hartland W; Schramek, Daniel.
Affiliation
  • Dervovic D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Malik AA; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Chen ELY; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Narimatsu M; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Adler N; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Afiuni-Zadeh S; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Krenbek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Martinez S; Department of Pathology and Bacteriology, Klinik Floridsdorf, Vienna, Austria.
  • Tsai R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Boucher J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Berman JM; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, QC, Canada.
  • Teng K; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Ayyaz A; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Lü Y; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Mbamalu G; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Loganathan SK; Department of Biological Sciences, University of Calgary, Calgary, AB, Canada.
  • Lee J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Zhang L; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Guidos C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Wrana J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Valipour A; Department of Otolaryngology, Head and Neck Surgery, McGill University, Montreal, QC, Canada.
  • Roux PP; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
  • Reimand J; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
  • Jackson HW; Departments of Laboratory Medicine and Pathobiology, Immunology, University of Toronto, Toronto, ON, Canada.
  • Schramek D; SickKids Research Institute, University Health Network, Toronto, ON, Canada.
Nat Commun ; 14(1): 3150, 2023 05 31.
Article in En | MEDLINE | ID: mdl-37258521
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serpins / Fertilins / Lung Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Type: Article Affiliation country: Canada
Fulltext
Print
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PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serpins / Fertilins / Lung Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Type: Article Affiliation country: Canada