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MRI characterization of in vitro clots at 3T and 7T: A technical note.
Dumitriu LaGrange, Daniela; Xin, Lijing; Lazeyras, François; Doyle, Karen M; Wanke, Isabel; Lövblad, Karl-Olof.
Affiliation
  • Dumitriu LaGrange D; Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address: Daniela.DumitriuLagrange@unige.ch.
  • Xin L; CIBM Center for Biomedical Imaging, Switzerland; Ecole Polytechnique Fédérale de Lausanne (EPFL), Animal Imaging and Technology, Lausanne, Switzerland.
  • Lazeyras F; Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland; CIBM Center for Biomedical Imaging, Switzerland.
  • Doyle KM; Department of Physiology, University of Galway, Ireland; CURAM, Science Foundation Ireland (SFI) Centre for Research in Medical Devices, University of Galway, Ireland.
  • Wanke I; Division of Neuroradiology, Klinik Hirslanden, Zurich, Switzerland; Swiss Neuroradiology Institute, Zurich, Switzerland; Division of Neuroradiology, University of Essen, Essen, Germany.
  • Lövblad KO; Division of Diagnostic and Interventional Neuroradiology, HUG Geneva University Hospitals, Geneva, Switzerland; Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
J Neuroradiol ; 51(1): 38-42, 2024 Feb.
Article in En | MEDLINE | ID: mdl-37364745
ABSTRACT
In acute ischemic stroke, the composition of the occlusive clot can be associated with the underlying pathophysiology and the response to treatment. For these reasons, it is important to characterize the clot composition from clinical scans. We examine the ability of 3T and 7T MRI to distinguish the composition of in vitro clots, using quantitative T1 and T2*, alternatively R2*, mapping. When comparing the two field strengths, we found a tradeoff between sensitivity for clot composition and confidence in the clot depiction associated with spatial resolution. The loss of sensitivity at 7T can be mitigated by combining the T1 and T2* signals.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Ischemic Stroke Limits: Humans Language: En Journal: J Neuroradiol Year: 2024 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Ischemic Stroke Limits: Humans Language: En Journal: J Neuroradiol Year: 2024 Type: Article