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Glycyrrhiza polysaccharides inhibits PRRSV replication.
Yang, Youbing; Liu, Yongjian; Lou, Ran; Lei, Ying; Li, Gan; Xu, Zhiqian; You, Xiangbin.
Affiliation
  • Yang Y; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
  • Liu Y; Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China.
  • Lou R; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
  • Lei Y; Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China.
  • Li G; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
  • Xu Z; Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China.
  • You X; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Virol J ; 20(1): 140, 2023 07 05.
Article in En | MEDLINE | ID: mdl-37408066
Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we studied the antiviral activity of glycyrrhiza polysaccharide against porcine reproductive and respiratory syndrome virus (PRRSV), a virus of the Arteriviridae family, with a high rate of variation and has caused huge economic losses to the pig industry in various countries since its discovery. Our results show that GCP can inhibit PRRSV replication in a dose-dependent manner. Furthermore, GCP could inhibit the mRNA expression of receptor genes CD163 and NF-κB p65 and promote the mRNA expression of the SLA-7 gene. Because of these results, GCP can be used as a candidate drug to prevent and treat PRRS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Porcine respiratory and reproductive syndrome virus / Porcine Reproductive and Respiratory Syndrome / Glycyrrhiza Limits: Animals Language: En Journal: Virol J Journal subject: VIROLOGIA Year: 2023 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Porcine respiratory and reproductive syndrome virus / Porcine Reproductive and Respiratory Syndrome / Glycyrrhiza Limits: Animals Language: En Journal: Virol J Journal subject: VIROLOGIA Year: 2023 Type: Article Affiliation country: China