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Effects of running a marathon on sclerostin and parathyroid hormone concentration in males aged over 50.
Zagrodna, Aleksandra; Ksiazek, Anna; Slowinska-Lisowska, Malgorzata; Chmura, Jan; Ponikowski, Piotr; Lombardi, Giovanni.
Affiliation
  • Zagrodna A; Department of Biological and Medical Basis of Sport, Faculty of Physical Education and Sports, Wroclaw University of Health and Sport Sciences, Wroclaw, Poland.
  • Ksiazek A; Department of Biological and Medical Basis of Sport, Faculty of Physical Education and Sports, Wroclaw University of Health and Sport Sciences, Wroclaw, Poland.
  • Slowinska-Lisowska M; Department of Biological and Medical Basis of Sport, Faculty of Physical Education and Sports, Wroclaw University of Health and Sport Sciences, Wroclaw, Poland.
  • Chmura J; Department of Biological and Motor Sport Bases, Faculty of Physical Education and Sports, Wroclaw University of Health and Sport Sciences, Wroclaw, Poland.
  • Ponikowski P; Department of Heart Diseases, Medical University, Wroclaw, Poland.
  • Lombardi G; Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Milano, Italy.
J Sports Sci ; 41(8): 796-802, 2023 Jun.
Article in En | MEDLINE | ID: mdl-37506230
ABSTRACT
The aim of our study was to verify whether running a marathon (32nd Wroclaw Marathon) was associated with changes in sclerostin and intact PTH (iPTH) concentration in middle-aged males. We enrolled 33 males who completed the marathon race. Blood samples were taken 60 minutes before (V1), immediately after (V2), and 7 days after the run (V3). The mean serum sclerostin concentration was 42.4 ± 10.8 pmol/L at V1, increased to 62.9 ± 12.6 pmol/L at V2 (t= -11.206; p < 0.001) and returned to baseline in V3 (t = 8.344; p < 0.001, V3 vs. V2). A similar trend was recorded for iPTH (t= -7.440; p < 0.001, for V2 vs. V1; t = 6.229; p < 0.001, for V3 vs. V2), at V3, iPTH levels remained significantly higher than V1 (t= -2.759; p = 0.010). The results of our study suggest that, in middle-aged males, running a marathon affects skeletal metabolism by activating two counteracting mechanisms, although temporarily overlapping first, by a sudden inhibition of bone formation, through induction sclerostin expression and, secondly, by a long-lasting induction of PTH, which also guarantees the maintenance of adequate circulating levels of calcium. The net effect would be the maintenance of adequately high levels of circulating calcium to be used for neuromuscular activity and muscle contraction.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parathyroid Hormone / Calcium Limits: Humans / Male / Middle aged Language: En Journal: J Sports Sci Year: 2023 Type: Article Affiliation country: Poland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parathyroid Hormone / Calcium Limits: Humans / Male / Middle aged Language: En Journal: J Sports Sci Year: 2023 Type: Article Affiliation country: Poland