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Spatial analyses of immune cell infiltration in cancer: current methods and future directions: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.
Page, David B; Broeckx, Glenn; Jahangir, Chowdhury Arif; Verbandt, Sara; Gupta, Rajarsi R; Thagaard, Jeppe; Khiroya, Reena; Kos, Zuzana; Abduljabbar, Khalid; Acosta Haab, Gabriela; Acs, Balazs; Akturk, Guray; Almeida, Jonas S; Alvarado-Cabrero, Isabel; Azmoudeh-Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Bellolio, Enrique R; Bheemaraju, Vydehi; Blenman, Kim Rm; Botinelly Mendonça Fujimoto, Luciana; Bouchmaa, Najat; Burgues, Octavio; Cheang, Maggie Chon U; Ciompi, Francesco; Cooper, Lee Ad; Coosemans, An; Corredor, Germán; Dantas Portela, Flavio Luis; Deman, Frederik; Demaria, Sandra; Dudgeon, Sarah N; Elghazawy, Mahmoud; Ely, Scott; Fernandez-Martín, Claudio; Fineberg, Susan; Fox, Stephen B; Gallagher, William M; Giltnane, Jennifer M; Gnjatic, Sacha; Gonzalez-Ericsson, Paula I; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G; Harbhajanka, Aparna; Hardas, Alexandros; Hart, Steven N; Hartman, Johan; Hewitt, Stephen; Hida, Akira I.
Affiliation
  • Page DB; Earle A Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
  • Broeckx G; Department of Pathology, GZA-ZNA Hospitals, Antwerp, Belgium.
  • Jahangir CA; Centre for Oncological Research (CORE), MIPPRO, Faculty of Medicine, Antwerp University, Antwerp, Belgium.
  • Verbandt S; UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland.
  • Gupta RR; Digestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Thagaard J; Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY, USA.
  • Khiroya R; Technical University of Denmark, Kongens Lyngby, Denmark.
  • Kos Z; Visiopharm A/S, Hørsholm, Denmark.
  • Abduljabbar K; Department of Cellular Pathology, University College Hospital, London, UK.
  • Acosta Haab G; Department of Pathology and Laboratory Medicine, BC Cancer Vancouver Centre, University of British Columbia, Vancouver, BC, Canada.
  • Acs B; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
  • Akturk G; Hospital Maria Curie, Buenos Aires, Argentina.
  • Almeida JS; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Alvarado-Cabrero I; Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.
  • Azmoudeh-Ardalan F; Translational Molecular Biomarkers, Merck & Co Inc, Kenilworth, NJ, USA.
  • Badve S; National Cancer Institute, Division of Cancer Epidemiology and Genetics (DCEG), Rockville, MD, USA.
  • Baharun NB; Oncology Hospital, Star Medica Centro, Mexico.
  • Bellolio ER; Tehran University of Medical Sciences, Tehran, Iran.
  • Bheemaraju V; Pathology and Laboratory Medicine, Emory University School of Medicine, Emory University Winship Cancer Institute, Atlanta, GA, USA.
  • Blenman KR; The National University of Malaysia, Kuala Lumpur, Malaysia.
  • Botinelly Mendonça Fujimoto L; Departamento de Anatomía Patológica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile.
  • Bouchmaa N; Department of Pathology, Narayana Medical College, Nellore, India.
  • Burgues O; Internal Medicine Section of Medical Oncology and Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Cheang MCU; Computer Science, Yale School of Engineering and Applied Science, New Haven, CT, USA.
  • Ciompi F; Amazonas Federal University, Manaus, Brazil.
  • Cooper LA; Institute of Biological Sciences, Faculty of Medical Sciences, Mohammed VI Polytechnic University (UM6P), Ben-Guerir, Morocco.
  • Coosemans A; Pathology Department, Hospital Cliníco Universitario de Valencia/Incliva, Valencia, Spain.
  • Corredor G; Head of Integrative Genomics Analysis in Clinical Trials, ICR-CTSU, Division of Clinical Studies, Institute of Cancer Research, London, UK.
  • Dantas Portela FL; Radboud University Medical Center, Department of Pathology, Nijmegen, The Netherlands.
  • Deman F; Department of Pathology, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
  • Demaria S; Department of Oncology, Laboratory of Tumor Immunology and Immunotherapy, KU Leuven, Leuven, Belgium.
  • Dudgeon SN; Biomedical Engineering Department, Emory University, Atlanta, GA, USA.
  • Elghazawy M; Hospital Universitário Getúlio Vargas, Manaus, Brazil.
  • Ely S; Department of Pathology, GZA-ZNA Hospitals, Antwerp, Belgium.
  • Fernandez-Martín C; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
  • Fineberg S; Department of Pathology, Weill Cornell Medicine, New York, NY, USA.
  • Fox SB; Conputational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
  • Gallagher WM; University of Surrey, Guildford, UK.
  • Giltnane JM; Ain Shams University, Cairo, Egypt.
  • Gnjatic S; Translational Pathology, Translational Sciences and Diagnostics/Translational Medicine/R&D, Bristol Myers Squibb, Princeton, NJ, USA.
  • Gonzalez-Ericsson PI; Instituto Universitario de Investigación en Tecnología Centrada en el Ser Humano, HUMAN-tech, Universitat Politècnica de València, Valencia, Spain.
  • Grigoriadis A; Montefiore Medical Center and the Albert Einstein College of Medicine, New York, NY, USA.
  • Halama N; Department of Pathology, Peter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.
  • Hanna MG; UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland.
  • Harbhajanka A; Genentech, South San Francisco, CA, USA.
  • Hardas A; Department of Oncological Sciences, Medicine Hem/Onc, and Pathology, Tisch Cancer Institute - Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Hart SN; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Hartman J; Cancer Bioinformatics, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
  • Hewitt S; Breast Cancer Now Research Unit, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
  • Hida AI; Translational Immunotherapy, German Cancer Research Center, Heidelberg, Germany.
J Pathol ; 260(5): 514-532, 2023 08.
Article in En | MEDLINE | ID: mdl-37608771
ABSTRACT
Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colonic Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Pathol Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colonic Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Pathol Year: 2023 Type: Article Affiliation country: United States