Treponema pallidum promoted microglia apoptosis and prevented itself from clearing by human microglia via blocking autophagic flux.

Hu, Yun-Ting; Wu, Kai-Xuan; Wang, Xiao-Tong; Zhao, Yuan-Yi; Jiang, Xiao-Yong; Liu, Dan; Tong, Man-Li; Liu, Li-Li

Hu, Yun-Ting; Wu, Kai-Xuan; Wang, Xiao-Tong; Zhao, Yuan-Yi; Jiang, Xiao-Yong; Liu, Dan; Tong, Man-Li; Liu, Li-Li.

Affiliation

Hu YT; Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Wu KX; Department of Clinical Laboratory, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, China.
Wang XT; Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Zhao YY; Department of Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, China.
Jiang XY; Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Liu D; Department of Dermatology, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, China.
Tong ML; Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Liu LL; Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

PLoS Pathog ; 19(8): e1011594, 2023 08.

Article in En | MEDLINE | ID: mdl-37611054

Subject(s)

Microglia; Neurosyphilis; Humans; Animals; Treponema pallidum/genetics; Zebrafish; Autophagy; Apoptosis

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microglia / Neurosyphilis Limits: Animals / Humans Language: En Journal: PLoS Pathog Year: 2023 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google